Clinical studies have established that high-calcium dietary supplements by themselves do not reliably increase bone density or reduce fracture risk.1, 2 Other nutrients are required. 3 The formation of new bone is really a complex process that involves first, building a scaffolding—the bone matrix—then adding in calcium and other minerals to produce hardness and strength.3, 4 This bone matrix is roughly comparable to the “rebar” that is set in place prior to pouring concrete. The bone’s “concrete” is formed at the end as hard mineral crystals that naturally include not just calcium but magnesium, strontium and other minerals.5
The bone matrix is a molecular network primarily of large collagen molecules, interspersed with smaller amounts of other proteins and with large protein-carbohydrate molecules (“glycosaminoglycans”). 5 The ascorbic acid (vitamin C) this formula provides is a necessary factor for the enzymes that make collagen.6 The formula’s complement of other nutrients is designed to enable the bone cells to build healthy bone matrix and achieve full bone mineralization. But this formula avoids supplying more calcium than the bone matrix can accommodate, especially since recent clinical findings suggest that calcium supplements not balanced by other key bone nutrients may create unnecessary health risks.7, 8
This formula’s highly active vitamin D3 is converted by the body into a master hormone that regulates calcium activity, not just in bone but all around the body.4 Bone requires adequate vitamin D to properly form and harden—poor vitamin D status is linked to increased risk for fracture.9 Poor muscle tone also contributes to risk of falls and consequent fracture, and vitamin D also helps preserve muscle function.10 The considerable clinical data makes clear that the higher one’s blood vitamin D level, lower the risk for falls and fractures.4,9
Men as much as women need generally high blood vitamin D levels to maintain a high bone density11 that protects against falls and fractures.9-11 Yet among adults 65 and older, at least 40 percent aredeficient in vitamin D.12 Calcium Bone Maker® Complex supplies a generous 1800 IU’s of cholecalciferol, the most active form of vitamin D.
Long known as essential for clotting (K stands for Koagulation4), vitamin K is also essential for “guiding” calcium to where it belongs (the bones, teeth and other hard tissues), rather than to the soft tissues where calcium’s accumulation can cause serious harm.7 Just as vitamin K activates the clotting proteins, it is essential to activate several proteins that bind calcium into the forming bone.4 These include osteocalcin, matrix Gla protein, periostin, and others.4, 13 Low dietary vitamin K2 intakes are linked to abnormal calcification of the coronaries and other large arteries, the heart valves, the heart muscle, or the kidney tubules.14 By providing the most active K2 form (MK-7) at 80 micrograms per day, this formula ensures the necessity of vitamin K for healthy bone maintenance.
The crucial bone building contributions of vitamin D, vitamin K, and calcium come together at osteocalcin, the second most abundant protein in bone after collagen.13 Osteocalcin strongly attracts and binds with calcium to calcify the collagen matrix.4 Osteocalcin’s production by the bone cells requires vitamin D, and its subsequent activation requires vitamin K.4,13