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Doctor's Best Calcium Bone Maker Complex 180 Capsules

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DRB10
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Product Description

Calcium Bone Maker Complex 180 Capsules

  • Bone health maintenance
  • Broad nutrient spectrum for healthy bone replacement.
  • Optimized to ensure safe and effective calcium utilization.
  • No magnesium oxide or other poorly absorbed ingredients.
  • Promotes skeletal, muscular, overall health and well-being.
Bone is living tissue, and this formula supplies key bone nutrients in their most bioactive forms. Ossein microcrystalline hydroxyapatite complex supplies organic calcium with natural bone growth factors. Vitamin C assists bone matrix formation. Vitamin and K are crucial to matrix calcification, along magnesium, potassium, zinc, copper, manganese, and boron. Calcium Bone Maker Complex represents the most advanced clinical understanding of bone health.
 
*More information below supplement facts*
 
cbmfacts.jpg

Calcium Is Not Sufficient to Build Bone

Clinical studies have established that high-calcium dietary supplements by themselves do not reliably increase bone density or reduce fracture risk.1, 2 Other nutrients are required. 3 The formation of new bone is really a complex process that involves first, building a scaffolding—the bone matrix—then adding in calcium and other minerals to produce hardness and strength.3, 4 This bone matrix is roughly comparable to the “rebar” that is set in place prior to pouring concrete. The bone’s “concrete” is formed at the end as hard mineral crystals that naturally include not just calcium but magnesium, strontium and other minerals.5

The bone matrix is a molecular network primarily of large collagen molecules, interspersed with smaller amounts of other proteins and with large protein-carbohydrate molecules (“glycosaminoglycans”). 5 The ascorbic acid (vitamin C) this formula provides is a necessary factor for the enzymes that make collagen.6 The formula’s complement of other nutrients is designed to enable the bone cells to build healthy bone matrix and achieve full bone mineralization. But this formula avoids supplying more calcium than the bone matrix can accommodate, especially since recent clinical findings suggest that calcium supplements not balanced by other key bone nutrients may create unnecessary health risks.7, 8

Vitamin D Enables Calcium to Build Bone

This formula’s highly active vitamin D3 is converted by the body into a master hormone that regulates calcium activity, not just in bone but all around the body.4 Bone requires adequate vitamin D to properly form and harden—poor vitamin D status is linked to increased risk for fracture.9 Poor muscle tone also contributes to risk of falls and consequent fracture, and vitamin D also helps preserve muscle function.10 The considerable clinical data makes clear that the higher one’s blood vitamin D level, lower the risk for falls and fractures.4,9

Men as much as women need generally high blood vitamin D levels to maintain a high bone density11 that protects against falls and fractures.9-11 Yet among adults 65 and older, at least 40 percent aredeficient in vitamin D.12 Calcium Bone Maker® Complex supplies a generous 1800 IU’s of cholecalciferol, the most active form of vitamin D.

Vitamin K Synergizes with Vitamin D to Manage Calcium

Long known as essential for clotting (K stands for Koagulation4), vitamin K is also essential for “guiding” calcium to where it belongs (the bones, teeth and other hard tissues), rather than to the soft tissues where calcium’s accumulation can cause serious harm.7 Just as vitamin K activates the clotting proteins, it is essential to activate several proteins that bind calcium into the forming bone.4 These include osteocalcin, matrix Gla protein, periostin, and others.4, 13 Low dietary vitamin K2 intakes are linked to abnormal calcification of the coronaries and other large arteries, the heart valves, the heart muscle, or the kidney tubules.14 By providing the most active K2 form (MK-7) at 80 micrograms per day, this formula ensures the necessity of vitamin K for healthy bone maintenance.

The crucial bone building contributions of vitamin D, vitamin K, and calcium come together at osteocalcin, the second most abundant protein in bone after collagen.13 Osteocalcin strongly attracts and binds with calcium to calcify the collagen matrix.4 Osteocalcin’s production by the bone cells requires vitamin D, and its subsequent activation requires vitamin K.4,13

Magnesium And Other Minerals Also Essential to Bone

 

Magnesium is essential for healthy bone formation, and especially to support and balance calcium.15,16 Magnesium insufficiency is linked with abnormal lowering of calcium in the blood.17 Some 50-60 percent of the body’s magnesium actually is located in bone.16

Several other minerals are crucial for making healthy bone. Zinc is required to make new bone matrix proteins.18 Copper is essential for enzymes that cross link collagen into the bone matrix, and also helps balance zinc.19 Manganese is required by enzymes that make glycoproteins for the bone matrix.20 Boron supports calcium and magnesium metabolism21 and probably also bone growth factors.22 Potassium supports calcium and magnesium utilization and helps conserve healthy bone mineral density.23
 

                                               Scientific References

  1. Reid IR, Bolland MJ, Grey A. Osteoporos Int 2008;19:1119-1123.
  2. Bischoff-Ferrari HA, Dawson-Hughes B, Baron JA, others. Am J Clin Nutr 2007;86:1780-1790.
  3. Yaegashi Y, Onoda T, Tanno K, others. Eur J Epidemiol 2008;23:219-225.
  4. Kidd PM. Altern Med Rev 2010;15:199-122.
  5. Feng X. Curr Chem Biol 2009;3:189-196.
  6. Peterkofsky B. Am J Clin Nutr 1991;54:1135S–1140S.
  7. Bolland MJ, Avenell A, Baron JA, others. BMJ (Brit Med J) 2010;341:c3691 (Online First-9 pages).
  8. Russo D, Miranda I, Ruocco C, others. Kidney Int 2007;72:1255-1261.
  9. Dawson-Hughes B, Mithal A, Bonjour JP, others. Osteoporos Int 2010;21:1151-1154.
  10. Bischoff-Ferrari H. Dermatol Ther 2010;23:23-30.
  11. Bischoff-Ferrari HA, Kiel DP, Dawson-Hughes B, others. J Bone Miner Res 2009; 24:935-942.
  12. Barnard K, Colon-Emeric C. Am J Geriatr Pharmacother 2010;8:4-33.
  13. Berkner KL. Vitam Horm 2008;78:131-156.
  14. Beulens JW, Bots ML, Atsma F, others. Atherosclerosis 2009;203:489-493.
  15. Nishimuta M, Kodama N, Morikuni E, others. J Nutr Sci Vitaminol 2006;52:402-406.
  16. Standing Committee on the Scientific Evaluation of Dietary Reference Intakes, Food and Nutrition Board, Institute of Medicine. Washington, DC: National Academy Press; 1997.
  17. Killilea DW, Maier JAM. Magnes Res 2008;21:77-82.
  18. Strause L, Saltman P, Smith KT, others. J Nutr 1994;124:1060-64.
  19. Siegel RC, Piimeli SR, Martin GR. Biochemistry 1970;9:4486-4490.
  20. Leach RM, Muenster AM, Wein E. Arch Biochem Biophys 1969;133: 22-28.
  21. Hunt CD, Herbel JL, Nielsen FH. Am J Clin Nutr 1997;65:803-813.
  22. Hakki SS, Bozkurt BS, Hakki EE. J Trace Elem Med Biol 2010 Aug 2. [Epub ahead of print]
  23. Tucker KL, Hannan MT, Chen H, others. Am J Clin Nutr 1999;69:727-736.
  24. Heaney RP, Dowell MS, Hale CA, Bendich A. J Am Coll Nutr 2003;22:142-146.
  25. Hunt CD, Johnson LK. Am J Clin Nutr 2007;86:1054-1063.
  26. Neilsen FH. Magnes Res 2004;17:197-210.
* These statements have not been evaluated by the FDA. This product is not intended to diagnose, cure or prevent any disease. 

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